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That title now belongs to Novo Nordisk A/S semaglutide, approved as Ozempic in 2017 to treat diabetes and as Wegovy in 2021 to help with weight loss.
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FDA-approved as Zepbound (obesity) and Mounjaro (T2D)

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BP lowering has not been consistently observed in two recent double-blind controlled clinical trials evaluating ambulatory BP as the primary end point
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