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In addition, those on the drugs reported that they felt less of a buzz from intoxication, researchers say

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In a literature review by Araj-Khodaei et al., it was stated that Berberine induces GLP-1 insulin secretion by altering the gut biome, and promoting the secretion of short chain fatty acids in the large intestine [6]

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Cerebral Cortex, 32, 1269-1285