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The relationship between diabetes and cognitive impairment involves many aspects, including central insulin signal transduction, nerve fiber damage caused by hyperglycemia, neuritis, oxidative stress, bloodbrain barrier damage, vascular neuropathy, changes in the dopaminergic system, and the effects of advanced glycation end products on metabolism and energy (Figure 1)

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The clinical data is extensive, the prescribing infrastructure is well-established, and both injectable and oral formulations are available

doi: 10.1016/0014-5793(95)01006-Z 119 FalkoJMCrockettSECatalandSMazzaferriEL

It features detailed analyses such as PORTERs Five Forces, SWOT, and PESTLE, as well as assessments of technological trends and the competitive landscape

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