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The role of hypothalamic tanycytes has been studied in different types of GLP-1RAs

Pflugers Arch 438:299306 Gromada J, Holst JJ, Rorsman P (1998) Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1

Collaboration assists with patient questions on social media

Diabetes 68 , 871878 (2019)

Retatrutide is frequently discussed in scientific literature as a triple receptor agonist model because it is studied across GLP-1, GIP, and glucagon receptor pathways

But Ben, like you're saying, the big issue is that even with the slightly higher dose of liraglutide, it yields long term on average across populations about an 8% BMI reduction, which is meaningful, but it's not that meaningful