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However, extrapolating from classic diet trials to GLP-1 pharmacotherapy is imperfect: appetite suppression changes habitual intake patterns, and the degree to which patients spontaneously maintain protein targets and resistance loading during GLP-1 therapy is variable in real-world practice

Kosin Med

Extracted variables included prescription dates and prescribed weekly doses, which were used to determine initial dose, maximum dose achieved, dose escalation patterns, and treatment duration based on prescription span (first to last recorded prescription)

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The half-life of retatrutide is approximately six days, achieved through acylation with a fatty diacid moiety