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Competing interests The authors declare no competing interests

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The global transfer of plants, animals, disease, and food between the Eastern and Western hemispheres during the colonization of the Americas is called the Middle Passage Columbian Exchange Triangular Trade Interhemisphere Exchange 2

The classic mechanisms of carcinogen metabolic activation to DNA adducts, leading to miscoding and mutations in critical growth control genes, applies to this mixture but some aspects are difficult to establish because of the complexity of the exposure

doi:10.1371/journal.pmed.1000216

Nature 303 , 468472 (1983)