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Oncology Monoclonal antibodies (mAbs) are biologics therapies widely used in the treatment of various cancers [110]

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During apoptosis, several biologically active substances act in different phases, mainly influence intrinsic apoptosis

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In addition, inflammatory factors in the bloodstream can regulate microglial activation and impact the synthesis of monoamine neurotransmitters either by compromising the blood-brain barrier or by directly infiltrating the brain parenchyma (Wang et al., 2018a)